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Decreased Antioxidant Vitamin Concentration May Be a Risk Factor for Recurrent Carotid Stenosis

Regional Vascular and Endovascular Unit, Belfast City Hospital, Belfast, Northern Ireland, julieann.reid{at}virgin.net

Louis L. Lau, MD, FRCS

Regional Vascular and Endovascular Unit, Belfast City Hospital, Belfast, Northern Ireland

Raymond J. Hannon, MD, FRCS

Regional Vascular and Endovascular Unit, Belfast City Hospital, Belfast, Northern Ireland

Bernard Lee, FRCS

Regional Vascular and Endovascular Unit, Belfast City Hospital, Belfast, Northern Ireland

Ian S. Young, BSc, MRCP, MRCPath, MD, FRCP, FRCPath

Queens University Belfast

Chee V. Soong, MD, FRCS

Regional Vascular and Endovascular Unit, Belfast City Hospital, Belfast, Northern Ireland

Carotid endarterectomy has been found to be associated with a transient increase in systemic oxidative stress, and this has been shown to be a predictor of restenosis. The aim of this study was to determine the incidence of early recurrent stenosis and investigate a possible role of oxidative stress in its development by measuring the concentration of antioxidant vitamins. Patients undergoing carotid endarterectomy between August 2001 and February 2003 were included in the study. A preoperative blood sample was analyzed for antioxidant vitamin concentrations. All patients were followed up by duplex scans 3 and 12 months postoperatively. Ninety-three patients (101 carotid endarterectomies) were recruited. Nine arteries had developed restenosis by 12 months. Those patients who developed recurrent stenosis had significantly lower vitamin C concentrations (19.10 ± 3.69 vs 30.11 ± 19.10, P = .02) than those who did not. This study suggests that low antioxidant vitamin levels may predispose to early restenosis after carotid endarterectomy.

Key Words: carotid endarterectomy • restenosis • vitamin C • antioxidant

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Vascular and Endovascular Surgery, Vol. 41, No. 4, 330-334 (2007)
DOI: 10.1177/1538574407302750


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Reid, J. A. Articles by Soong, C. V. Search for Related Content PubMed PubMed Citation Articles by Reid, J. A. Articles by Soong, C. V. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Antioxidants Hazardous Substances DB ASCORBIC ACID SODIUM ASCORBATE Social Bookmarking                         What's this?