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Associations Between Statin Treatment and Markers of Inflammation, Vasoconstriction, and Coagulation in Patients With Abdominal Aortic Aneurysm

University of Lund, Vascular Centre, Malmö University Hospital, Malmö, Sweden, anders.gottsater{at}med.lu.se

Despina Flondell-Site, MD

University of Lund, Vascular Centre, Malmö University Hospital, Malmö, Sweden

Tilo Kölbel, MD, PhD

University of Lund, Vascular Centre, Malmö University Hospital, Malmö, Sweden

Bengt Lindblad, MD, PhD

University of Lund, Vascular Centre, Malmö University Hospital, Malmö, Sweden

The association of statins with markers of inflammation, vasoconstriction, and coagulation was evaluated in 325 patients with abdominal aortic aneurysm with respect to statin treatment or not. Variables evaluated included routine laboratory markers, lipids, homocysteine, endothelin-1, matrix metalloproteinases (MMP)-2 and -9, and activated protein C-protein C inhibitor (APC-PCI) complex. Statin-treated patients were more often male (85% vs 75%; P = .024) and had ischemic heart disease (57% vs 19%; P < .0001). They showed lower levels of cholesterol (P < .0001), homocysteine (P = .027), MMP-9 (P = .038), and endothelin-1 (P = .005), and higher levels of APC-PCI complex (P = .042). Differences persisted in logistic regression for cholesterol (P < .0001), APC-PCI complex (P = .034), and homocysteine (P = .021). Statin-treated patients with abdominal aortic aneurysm show higher APC-PCI complex and lower homocysteine levels. Whether this translates into lower risk for aneurysm expansion or rupture will be evident from further follow-up.

Key Words: abdominal aortic aneurysm • statins • inflammation • homocysteine • APC-PCI complex

This version was published on January 1, 2009

Vascular and Endovascular Surgery, Vol. 42, No. 6, 567-573 (2009)
DOI: 10.1177/1538574408320027


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