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Vascular and Endovascular Surgery
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Mesenteric Venous Thrombosis With Bowel Infarction and Hyperhomocysteinemia Due to Homozygous Methylenetetrahydrofolate Reductase C677T Genotype

Cristina Hotoleanu, MD

Medical Clinic, University of Medicine and Pharmacy, Cluj-Napoca, Romania, cristinaiga{at}yahoo.com

Octavian Andercou, MD, PhD

Surgical Clinic, University of Medicine and Pharmacy, Cluj-Napoca, Romania

Aurel Andercou, MD, PhD

Surgical Clinic University of Medicine and Pharmacy, Cluj-Napoca, Romania

The case of a 30-year-old man with bowel infarction due to mesenteric venous thrombosis and multiple risk factors, including mild hyperhomocysteinemia due to methylenetetrahydrofolate reductase C677T polymorphism and recent abdominal surgery, is reported. His clinical manifestation consisted of persistent abdominal pain; complementary examinations showed nonspecific findings such as leukocytosis and dilated loops of the bowel. The diagnosis of mesenteric venous thrombosis with bowel infarction was made during laparotomy and confirmed by anatomopathologic examination. He underwent segmental resection associated with lifelong anticoagulant therapy and vitamin B supplementation with a favorable course.

Key Words: mesenteric venous thrombosis • hyperhomocysteinemia • methylenetetrahydrofolate reductase C677T polymorphism

Vascular and Endovascular Surgery, Vol. 42, No. 5, 477-481 (2008)
DOI: 10.1177/1538574408316141
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