This Article Full Text (PDF) All Versions of this Article: 1538574408316138v1 42/4/341    most recent References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Hogh, A. L. Articles by Ostergaard, L. Search for Related Content PubMed PubMed Citation Articles by Hogh, A. L. Articles by Ostergaard, L. Social Bookmarking                         What's this?

C-Reactive Protein Predicts Future Arterial and Cardiovascular Events in Patients With Symptomatic Peripheral Arterial Disease

Department of Vascular Surgery, Vascular Research Unit, Viborg Hospital, Viborg, a_l_hogh{at}yahoo.dk

Jette Joensen, MD, PhD

Department of Vascular Surgery, Rigshospitalet, University Hospital of Copenhagen, Copenhagen

Jes S. Lindholt, MD, PhD

Department of Vascular Surgery, Vascular Research Unit, Viborg Hospital, Viborg

Martin R. Jacobsen, MD

Department of Infectious Diseases, Skejby Sygehus, University Hospital of Aarhus, Aarhus Denmark

Lars Ostergaard, MD, PhD

Department of Infectious Diseases, Skejby Sygehus, University Hospital of Aarhus, Aarhus Denmark

High-sensitivity C-reactive protein is associated with increased risk of cardiovascular events. Consequently, the predictive value of this protein in patients with symptomatic peripheral arterial disease was examined. In all, 452 patients with symptomatic peripheral arterial disease had high-sensitivity C-reactive protein measured at baseline (mean follow-up = 2.1 ± 1.4 years). Events were defined as primary (death, amputation, or peripheral revascularization) or secondary (lower limb thrombosis, myocardial infarction, or stroke).The level of high-sensitivity C-reactive protein was significantly higher among those dying (P = .04), those who needed amputation (P = .01), and those developing an overall secondary endpoint (P = .02). By receiver-operating characteristic curve analysis, the optimal cutoff point was constantly approximately 10 to 20 mg/L with a sensitivity and specificity of 56% to 63% and 54% to 56%, respectively. Baseline levels of high-sensitivity C-reactive protein are associated with future arterial events in symptomatic peripheral arterial disease patients but cannot stand alone as a predictive tool.

Key Words: atherosclerosis • C-reactive protein • peripheral arterial disease • cardiovascular deaths • prospective

This version was published on August 1, 2008

Vascular and Endovascular Surgery, Vol. 42, No. 4, 341-347 (2008)
DOI: 10.1177/1538574408316138


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?