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Low-Dose Aspirin May Prevent Growth and Later Surgical Repair of Medium-Sized Abdominal Aortic Aneurysms

Department of Vascular Surgery, Vascular Research Unit, Viborg Hospital, Viborg, Jes.S.Lindholt{at}Sygehusviborg.dk

Henrik T. Sorensen, DMSc, MD

Denmark Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark

Jean B. Michel, PhD, MD

Inserm Unit 698, Cardiovascular Remodeling, Xavier Bichat Hospital, Paris, France

Henrik F. Thomsen, PhD

Denmark Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark

Eskild W. Henneberg, MD

Department of Vascular Surgery, Vascular Research Unit, Viborg Hospital, Viborg

Experimental data suggest that aspirin-induced platelet inhibition may retard growth of abdominal aortic aneurysms. In this article, whether low-dose aspirin use is associated with reduced aneurysm progression and subsequent need for surgery is examined. In this observational cohort study within a screening trial, 148 patients with small aneurysms (maximum diameter 30-48 mm) annually are followed. Patients were referred for surgery when the aneurysmal diameter exceeded 50 mm. Median follow-up time was 6.6 years. Among patients whose abdominal aortic aneurysms were initially 40 to 49 mm in size, the abdominal aortic aneurysm expansion rate for low-dose aspirin users compared with nonusers was 2.92 mm/y versus 5.18 mm/y (difference 2.27 mm/y, 95% CI, 0.42-4.11). No difference in expansion rates and risk ratios for operative repair was found for patients with abdominal aortic aneurysms <40 mm. For medium-sized abdominal aortic aneurysms, low-dose aspirin may prevent abdominal aortic aneurysm growth and need for subsequent repair, but residual confounding cannot be excluded.

Key Words: aneurysms • aspirin • follow-up studies • prevention • surgery

Vascular and Endovascular Surgery, Vol. 42, No. 4, 329-334 (2008)
DOI: 10.1177/1538574408315205


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