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Surgical Complications in a Hemophilia Patient With Factor VIII Inhibitor and Their Endovascular Management

Cambridge Vascular Unit, Addenbrooke's Hospital, Cambridge, United Kingdom, sadat.umar{at}gmail.com

Jag Naik, MD, FRCS

Cambridge Vascular Unit, Addenbrooke's Hospital, Cambridge, United Kingdom

Paul D. Hayes, MD, FRCS

Cambridge Vascular Unit, Addenbrooke's Hospital, Cambridge, United Kingdom

Hemophilia, an X-linked disorder due to clotting factors VIII or IX deficiency, is associated with recurrent hemorrhage into joints, soft tissue, and organs. Recombinant factor VIII concentrates are available for the treatment of bleeding complications. However, inhibitors to factor VIII develop in 25% to 35% of patients with severe hemophilia A, making the management of bleeding episodes more complex. The treatment of unusual metachronous ruptured aneurysms in a patient with hemophilia A with factor VIII inhibitor is presented, and the outcomes of endovascular and open operations are discussed.

Key Words: hemophilia • embolization • coiling • vertebral artery pseudoaneurysm • hemophilia arthropathy • hemophilia inhibitors

Vascular and Endovascular Surgery, Vol. 42, No. 2, 168-172 (2008)
DOI: 10.1177/1538574407309319


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