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This version was published on May 1, 2008
Vascular and Endovascular Surgery, Vol. 42, No. 2, 135-140 (2008)
DOI: 10.1177/1538574407311108

Activated Protein C—Protein C Inhibitor Complex in Patients With Abdominal Aortic Aneurysms: Is It Associated With Diameter and Growth Rate?

Tilo Kölbel, MD

Department of Vascular Diseases, Malmo University Hospital, tilo.kolbel{at}skane.se

Karin Strandberg, MD

Department of Clinical Chemistry Malmö University Hospital, Malmö, Sweden

Tobias Donath, MD

Department of Vascular Diseases, Malmo University Hospital

Ingrid Mattiasson, MD

Department of Vascular Diseases, Malmo University Hospital

Johan Stenflo, MD

Department of Clinical Chemistry Malmö University Hospital, Malmö, Sweden

Bengt Lindblad, MD

Department of Vascular Diseases, Malmo University Hospital

Increased thrombin activation was documented in patients with abdominal aortic aneurysm (AAA). Activated protein C—protein C inhibitor (APC—PCI) complex, a new biological marker of thrombin generation, was measured in a population of 232 patients with AAA and a control group, and the association between aneurysm size, growth rate, and APC—PCI was studied. The patients were divided into cohorts according to AAA diameter and compared with a control group. APC—PCI was significantly higher in all AAA cohorts (n = 232; median, 0.36 µg/L; 10th to 90th percentile, 0.18-1.01) compared with the control group (n = 41; median, 0.19 µg/L; 10th to 90th percentile, 0.11-0.31; P ≤ .001). APC—PCI correlated with AAA diameter (r = .22; P = .001), body mass index (r = –.19; P = .004), and age (r = .19; P = .004). APC—PCI did not correlate with AAA growth rate (r = .11; P = .14).

Key Words: aorta • aneurysm • coagulation • thrombus


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