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Lack of Association Between Chlamydophila Pneumoniae Seropositivity and Abdominal Aortic Aneurysm

Department of Clinical Bacteriology, University of Lund, Lund, Sweden

Elisabet Skagius, MD

Department of Surgery, University of Lund, Lund, Sweden

Ingrid Nilsson, PhD

Department of Laboratory Medicine, Division of Medical Microbiology, University of Lund, Lund, Sweden

Asa Ljungh, MD, PhD

Department of Laboratory Medicine, Division of Medical Microbiology, University of Lund, Lund, Sweden

Anders E. Henriksson, MD, PhD

Department of Surgery, University of Lund, Lund, Sweden, anders.henriksson{at}lvn.se

Chronic Chlamydophila pneumoniae infection has been suggested as a possible contributing factor for the development and expansion of abdominal aortic aneurysm (AAA). The relevance of C pneumoniae involved in the processes underlying aneurysmal rupture is unknown. The aim of this study was to examine the relationship between C pneumoniae seropositivity and AAA rupture. In a case-control study, 119 patients with AAA and 36 matched controls were prospectively investigated with C pneumoniae serology. Patients with ruptured AAA have similar levels of IgG antibodies against C pneumoniae as patients with an electively operated AAA, a small AAA, and controls. In conclusion, this study fails to demonstrate a connection between C pneumoniae seropositivity and AAA rupture.

Key Words: Chlamydophila pneumoniae • aortic aneurysm • abdominal • rupture

Vascular and Endovascular Surgery, Vol. 41, No. 3, 246-248 (2007)
DOI: 10.1177/1538574407301429


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