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Vascular and Endovascular Surgery
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Therapeutic Angiogenesis

Shant M. Vartanian, MD

Division of Vascular Surgery, University of California, San Francisco, California

Rajabrata Sarkar, MD, PhD

Division of Vascular Surgery, University of California, San Francisco, California, vartanians{at}surgery.ucsf.edu

Myocardial ischemia and peripheral vascular disease persist as significant clinical problems despite improved medical, surgical, and endovascular therapies. Advances in our understanding of the biological mechanisms that govern capillary neovascularization and collateral artery growth have enabled molecular therapies for revascularizing ischemic tissues. Generally known as therapeutic angiogenesis, this review summarizes the essential pre-clinical research and the major clinical trials of molecular therapies for ischemic disease. Early clinical experience has established the proof of principle, however, inconsistent and modest improvements in clinical outcomes have exposed the complexity of neovascularization and problems with transitioning basic science to clinical applicability.

Key Words: therapeutic angiogenesis • ischemia • molecular therapy • neovascularization

Vascular and Endovascular Surgery, Vol. 41, No. 3, 173-185 (2007)
DOI: 10.1177/1538574407302849
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