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Vascular and Endovascular Surgery
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Systemic Thrombolysis Using Tissue Plasminogen Activator for a Patient with Paradoxic Embolism: A Case Report

Zhen Fan, MD

Department of Surgery, Good Samaritan Hospital, Cincinnati, Ohio, Joy_Rusche{at}trihealth.com

Richard Roedersheimer, MD

Department of Surgery, Good Samaritan Hospital, Cincinnati, Ohio

Joann Lohr, MD

Department of Surgery, Good Samaritan Hospital, Cincinnati, Ohio

When thrombotic material that originates from deep venous thrombosis of the lower extremities is washed out into the pulmonary vasculature, pulmonary embolization occurs. Pulmonary embolism and associated acute peripheral ischemia suggest the diagnosis of paradoxic embolism, which is most often associated with a patent foramen ovale. Therapeutic options include anticoagulation, mechanical/chemical thrombus dissolution, inferior vena cava filtration, and closure of the intracardiac defect. The diagnosis and treatment are described of an elderly female who presented with lower extremity deep venous thrombosis and massive pulmonary embolism complicated by paradoxic emboli to the left subclavian artery as well as the celiac artery.

Key Words: deep venous thrombosis • pulmonary embolism • patent foramen ovale • anticoagulation therapy

Vascular and Endovascular Surgery, Vol. 41, No. 2, 136-139 (2007)
DOI: 10.1177/1538574406296212


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