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Custom-made Stent-Grafts for Aortic Aneurysm Repair Using Gianturco Z Stents and Woven Polyester: Healing in an Animal Model

Paris, Saint-Mandé, and Jouy en Josas, France

Isabelle Brocheriou, MD

Department of Pathology, CHU Pitié-Salpêtrière, Paris

Philippe Cluzel, MD

Department of Radiology, CHU Pitié-Salpêtrière, Paris

Jean-Dominique Singland, MD

Departments of Surgery, SSA Bégin, Saint-Mandé

Bruno Régnier, MSc

Paris, Saint-Mandé, and Jouy en Josas, France

Michel Bonnot, PhD

CRII, INRA, Jouy en Josas, France

Edouard Kieffer, MD

Paris, Saint-Mandé, and Jouy en Josas, France

The purpose of this study was to evaluate the healing at 6 months of aortic stent-grafts custom-made by using Z stents and woven polyester in an animal model. Stent-grafts were built by a published method using autoexpandable stainless steel stents continuously compiled with polyester sutures and covered with a woven polyester membrane. Fourteen stent-grafts of 3 different designs were deployed under fluoroscopic control into the thoracic and the abdominal aorta of 7 adult sheep. At 6 months, all the implants of the sheep that survived the implantation were angiographed and harvested for macroscopy and microscopy. All stentgrafts were implanted successfully and remained patent from then to the explantation procedure. All stent-grafts implanted among the 6 of 7 (86%) animals that survived after the implantation remained patent, stayed free from local complications, and did not migrate during more than 6 months. In all these cases during this period, the implant functioned as a satisfactory aortic substitute while the aortic segment containing the graft kept a normal structure. There was no adverse effects of the presence of the implant upon the aorta or the animal. Stent-grafts home-made according to the described methods gave results at 6 months in this animal model compatible with a safe clinical application among humans.

Vascular and Endovascular Surgery, Vol. 39, No. 1, 55-65 (2005)
DOI: 10.1177/153857440503900106


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