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Associations Between Renovascular Disease and Prevalent Cardiovascular Disease in the Elderly: A Population-Based Study

Division of Surgical Sciences Section on Vascular Surgery, Wake Forest University School of Medicine, Winston-Salem, NC

Kimberley J. Hansen, MD

Division of Surgical Sciences Section on Vascular Surgery, Wake Forest University School of Medicine, Winston-Salem, NC; Department of General Surgery, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1095 kjhansen{at}wfubmc.edu

Timothy E. Craven, MSPH

Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC

Anthony J. Bleyer, MD, MS

Department of Internal Medicine Section on Nephrology, Wake Forest University School of Medicine, Winston-Salem, NC

Gregory L. Burke, MD, MS

Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC

Pavel J. Levy, MD

Richard H. Dean, MD

Division of Surgical Sciences Section on Vascular Surgery, Wake Forest University School of Medicine, Winston-Salem, NC

Atherosclerotic renovascular disease (RVD) is a suspected contributor to the morbidity and mortality of cardiovascular disease (CVD) through its potential effects on blood pressure and excretory renal function as well as through its associations with other forms of CVD. However, population-based data regarding the associations between the presence of RVD and prevalent CVD are lacking. The Cardiovascular Health Study (CHS) is a prospective, multicenter cohort study of CVD among elderly Americans. As part of an ancillary study, participants in the Forsyth County, North Carolina, cohort of the CHS were invited to undergo renal duplex sonography (RDS) to establish the presence or absence of RVD (defined as any focal peak systolic velocity =1.8 m/second or the absence of a Doppler-shifted signal from an imaged artery). Demographic, risk factor, and prevalent CVD data were obtained from the CHS coordinating center and matched with ancillary study participants. Eight hundred thirty-four CHS participants (including 525 women [63%], 309 men [37%], 194 African-Americans [23%], and 635 Caucasians [76%]) with a mean age of 77.2 ±4.9 years underwent RDS examination. RVD was present in 57 participants (6.8%). Overall, clinical and/or subclinical manifestations of CVD were present in 603 participants (72.3%) at the time of RDS. Participants with RVD demonstrated a significantly greater prevalence of angina (p=0.002), previous myocardial infarction (p< 0.001), = 25% diameter-reducing internal carotid artery stenosis (p= 0.010), increased carotid intimal medial thickness (p= 0.003), and major electrocardiographic abnormalities (p= 0.013). Following adjustment for demographics and cardiovascular risk factors, the presence of RVD demonstrated a significant and independent association with prevalent coronary artery disease but not with prevalent cerebrovascular or lower extremity vascular disease. These results suggest important population-based associations between RVD and both clinical and subclinical manifestations of CVD, especially coronary artery disease.

Vascular and Endovascular Surgery, Vol. 38, No. 1, 25-35 (2004)
DOI: 10.1177/153857440403800103


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