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Vascular and Endovascular Surgery
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Reviews

Heparin-Induced Thrombocytopenia: Pathophysiology and Management

Leila Mureebe, MD

Donald Silver, MD

Division of Vascular Surgery, University of Missouri Health Sciences Center, Columbia, MO

Immune-mediated heparin-induced thrombocytopenia (HIT) is a well-defined syndrome. Clinical criteria (thrombocytopenia, resistance to heparin anticoagulation, or thromboses during heparin therapy) are defined, and serologic diagnostic tests are available. Earlier recognition of HIT syndrome has allowed for significant advances in therapy, leading to marked reductions in morbidity and mortality from HIT syndrome. This review addresses the epidemiology, pathobiology, and management of HIT syndrome

Vascular and Endovascular Surgery, Vol. 36, No. 3, 163-170 (2002)
DOI: 10.1177/153857440203600302
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