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Abdominal Aortic Aneurysm: Association Between Haptoglobin Phenotypes, Elastase Activity, and Neutrophil Count in the Peripheral Blood

Piotr Gutowski, MD, PhD

Department of General and Vascular Surgery, Pomeranian Medical University, Szczecin, Poland

Kazimierz Ciechanowski, MD, PhD

Department of Biochemistry and Chemistry, Pomeranian Medical University, Szczecin, Poland

Barbara Millo, PhD

Department of Clinical Biochemistry and Laboratory Diagnostics, Pomeranian Medical University, Szczecin, Poland

Piotr Wieczorek, PhD

Department of Biochemistry and Chemistry, Pomeranian Medical University, Szczecin, Poland

Miloslaw Cnotliwy, MD, PhD

Tomasz Michalak, MD, PhD

Tomasz Hamera, MD

Department of General and Vascular Surgery, Pomeranian Medical University, Szczecin, Poland

Jaroslaw Piatek, PhD

Department of Forensic Medicine, Pomeranian Medical University, Szczecin, Poland

To investigate the role of genetic factors on susceptibility to atherosclerotic arterial disease, the influence of haptoglobin phenotypes (Hp) on serum elastase activity, neutrophil count, and elastin concentration in the aorta was measured in patients with abdominal aortic aneurysm (AAA; n=52) and aortoiliac atherosclerotic occlusive disease (AOD; n=37). Findings (serum elastase activity, peripheral blood neutrophil count) were compared to a control group (CG) of 37 subjects without atherosclerosis. Hp phenotyping performed by starch-gel electrophoresis produced a haptoglobin-hemoglobin complex of three phenotypes: Hp1-1, Hp2-2, and Hp2-1.

Distribution of Hp phenotypes was similar in the three study groups (AAA, AOD, CG). Significant increases in serum elastase activity and neutrophil count was measured in Hp2-1 phenotype of AAA patients. Although the aorta wall of aneurysm patients contained less (p<0.001) elastin than that of AOD patients, no significant difference of aorta elastin concentration between the three Hp phenotypes, including Hp2-1, was measured. The postulated association of AAA susceptibility with Hp2-1 phenotype was supported by the study data that demonstrated an increase in serum elastase activity in patients undergoing AAA repair.

Vascular and Endovascular Surgery, Vol. 35, No. 5, 345-350 (2001)
DOI: 10.1177/153857440103500503


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