This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Urayama, H. Articles by Watanabe, Y. Search for Related Content PubMed Articles by Urayama, H. Articles by Watanabe, Y. Social Bookmarking                         What's this?

Autologous Blood Donation with Erythropoietin in Abdominal Aortic Aneurysm Repair: Special Reference to Blood Pressure and Hormonal Changes

First Department of Surgery, Kanazawa University School of Medicine, Kanazawa, Japan

Hiroshi Ohtake

First Department of Surgery, Kanazawa University School of Medicine, Kanazawa, Japan

Kanae Tawaraya

First Department of Surgery, Kanazawa University School of Medicine, Kanazawa, Japan

Yoh Watanabe

First Department of Surgery, Kanazawa University School of Medicine, Kanazawa, Japan

Recombinant erythropoietin (rEPO) is used in autologous blood donation, but its useful ness and side effects have not been evaluated thoroughly. A prospective clinical study was conducted in 20 patients with abdominal aortic aneurysm who underwent surgery following autologous blood predonation with rEPO therapy. The patients were 19 men and one woman ranging in age from 59 to 79 years old. The blood pressure was measured before and after blood withdrawal and rEPO injection, and before and after rEPO injection alone. The levels of endogenous EPO, prolactin, growth hormone, and thyroid hormones were compared before the first blood withdrawal and just before surgery. The volume of blood withdrawn was 800 mL (400 mL at each of two with drawals) within 2 weeks, while 6,000 units of rEPO were injected four times. The blood pressure dropped after blood withdrawal and rEPO injection, but it showed no marked change after rEPO injection alone. The mean value of hemoglobin was decreased from 13.8 to 12.4 g/dL in 2 weeks, and all patients received autologous blood transfusion during surgery. No declamping shock was noticed, and only 2 of the 20 patients needed homologous blood transfusion. The levels of growth hormone and thyroid hormones did not change, but that of prolactin increased following blood predonation with rEPO therapy. No significant change of endogenous EPO was observed.

Vascular and Endovascular Surgery, Vol. 34, No. 2, 157-162 (2000)
DOI: 10.1177/153857440003400207


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?