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Vascular and Endovascular Surgery
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Alteration in Collagen and Elastin Content in Varicose Veins

Massimo Chello

Department of Cardiovascular Surgery, Medical School of Catanzaro

Pasquale Mastroroberto

Department of Cardiovascular Surgery, Medical School of Catanzaro

Rossana Romano

Department of Clinical Chemistry, Ospedale Nuovo Pellegrini, Napoli

Francesco Cirillo

Department of Cardiovascular Surgery, Medical School of Catanzaro

Tullio Cusano

Department of General Surgery, Medical School of Catanzaro, Italy

Antonietta R. Marchese

Department of Cardiovascular Surgery, Medical School of Catanzaro

The nature and distribution of venous disease surrounding the development of varicose veins is controversial. Collagen and elastin are important components of the vein walls that affect their function. Collagen provides tensile strength, and elastin provides tissue elasticity

The amount of collagen and elastin was studied biochemically and histologically in two groups of human normal and varicose veins. The collagen content was higher in both dilatated and morphologically normal segments of varicose veins when compared with normal veins, whereas the elastin content was markedly decreased only in the dilatated segments of varicose veins. The ratio of thick to thin collagen fibers was almost invariable. These findings were consistent with the morphologic fibrosis that has regularly been described in varicose veins and emphasize the important role of elastin in providing the retractive force that opposes the development of dilatation and tortuosity of the vein wall.

Vascular and Endovascular Surgery, Vol. 28, No. 1, 23-27 (1994)
DOI: 10.1177/153857449402800104
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