SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Vascular and Endovascular Surgery
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by El-Gatit, A.
Right arrow Articles by William-Olsson, G.
Right arrow Search for Related Content
PubMed
Right arrow Articles by El-Gatit, A.
Right arrow Articles by William-Olsson, G.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Effects of Alprostadil Infusion During Extracorporeal Circulation on Blood Rheology and Postoperative Blood Loss

Abdusalam El-Gatit, M.D.

Department of Thoracic and Cardiovascular Surgery, Sahlgrens Hospital and Scandinavian Heart Center, Göteborg University, Göteborg, Sweden

Najib Al-Khaja, Ph.D.

Department of Thoracic and Cardiovascular Surgery, Sahlgrens Hospital and Scandinavian Heart Center, Göteborg University, Göteborg, Sweden

Ali Belboul, M.D., Ph.D.

Department of Thoracic and Cardiovascular Surgery, Sahlgrens Hospital and Scandinavian Heart Center, Göteborg University, Göteborg, Sweden

Donald Roberts, Ph.D.

Department of Thoracic and Cardiovascular Surgery, Sahlgrens Hospital and Scandinavian Heart Center, Göteborg University, Göteborg, Sweden

Göran William-Olsson, M.D., Ph. D.

Department of Thoracic and Cardiovascular Surgery, Sahlgrens Hospital and Scandinavian Heart Center, Göteborg University, Göteborg, Sweden

The authors have investigated the effects a low dose of alprostadil (synthetic prostaglandin E1: S-PGI1) infusion during cardiac surgery on blood rheology and postoperative blood loss. S-PGE1 (20 ng/kg/minute) was given to 13 patients undergoing aortocoronary bypass. Another 13 patients who received no S-PGE1 during bypass surgery served as controls. To assess blood rheology, blood samples for red and white cell filterability (RFR and WFR) and for platelet count were collected preoperatively, immediately after the end of extracorporeal circulation (ECC), and twenty-four hours later. Records of blood loss were taken twelve and twenty-four hours postoperatively. RFR, WFR, and platelet counts at twenty-four hours were significantly reduced in the control group as compared with the S-PGE1 group, p = 0.002, p = 0.004, and p = 0.0026, respectively. Concomitantly, the means of the postoperative blood loss at twelve and twenty-four hours were lower in the S-PGE1 group, p= 0.0001 and p=0.0004, respectively. Furthermore, the use of blood transfusion products was significantly less in the S-PGE, group, p < 0.02. These results showed that the use of S-PGE, during ECC preserves blood rheology in association with significant reductions in blood loss and in the need for blood transfusion postoperatively.

Vascular and Endovascular Surgery, Vol. 26, No. 7, 521-528 (1992)
DOI: 10.1177/153857449202600702
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement