SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Vascular and Endovascular Surgery
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Katircioglu, S. F.
Right arrow Articles by Bayazit, K.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Katircioglu, S. F.
Right arrow Articles by Bayazit, K.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Effects of Prostacyclin on Heparin Reversal with Protamine

S. Fehmi Katircioglu

Cardiovascular Surgery Clinic, Turkiye Yuksek Ihtisas Hospital

D. Süha Küçükaksu

Cardiovascular Surgery Clinic, Turkiye Yuksek Ihtisas Hospital

Mithat Bozdayi

Biochemistry Clinic, Türkiye Yüksek Ihtisas Hospital, Cardiovascular Surgery Clinic, Ankara, Türkey

Gül Saydam

Biochemistry Clinic, Türkiye Yüksek Ihtisas Hospital, Cardiovascular Surgery Clinic, Ankara, Türkey

I. Yaman Zorlutuna

Cardiovascular Surgery Clinic, Turkiye Yuksek Ihtisas Hospital

Oguz Tasdemir

Cardiovascular Surgery Clinic, Turkiye Yuksek Ihtisas Hospital

Kemal Bayazit

Cardiovascular Surgery Clinic, Turkiye Yuksek Ihtisas Hospital

This study was planned to show the beneficial effects of prostacyclin (PGI2) utilization on adverse effects of protamine. PGI2 was administered at a rate of 5 ng/kg/min. Twenty patients entered this study. Half of them received PGI2 whereas the others did not.

Right ventricular end-diastolic volume index and right ventricular stroke work index were 72 mL/m2 and 2.2 g.m/m2, respectively, after patients were weaned off the bypass and 79 and 1.5, respectively, at five minutes after pro tamine administration in the control group; these values were 88 and 3.2, re spectively, and 86 and 3, respectively, in the PGI2 group. Left ventricular stroke work index (g.m/m2) was 27.9 in the control group and 36.7 in the PGI2 group (p < 0.05) after protamine administration.

Thromboxane B2 levels (pmoL/mL) in coronary sinus (CS) blood were 251 in the control group and 90 in the PGI2 group at five minutes after protamine administration (p < 0.05). Myocardial blood flow was 174 mL in the control group and 245 mL in the PGI2 group at five minutes after protamine adminis tration (p < 0.05). Cyclic adenosine monophosphate (cAMP) and cyclic guano- sine monophosphate (cGMP) levels in CS blood were 17 pmoL/mL and 2.1 pmoL/mL, respectively, in the control group and 36 and 0.3, respectively, in the PGI2 group at five minutes after protamine administration. Leukotriene B4 level was 129 and 57 pmoL/mL in the control and PGI2 groups, respectively (at the same time as the cAMP measurement) (p < 0.05).

From the results of this study the authors conclude that adverse effects of heparin reversal with protamine can be reduced with the use of PGI2.

Vascular and Endovascular Surgery, Vol. 26, No. 6, 464-473 (1992)
DOI: 10.1177/153857449202600606
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement