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Vascular and Endovascular Surgery
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Hypofibrinolytic Activity after Total Joint Replacement

H. Kikuchi

Department of Orthopaedic Surgery, Kinki University School of Medicine

S. Tanaka

Department of Orthopaedic Surgery, Kinki University School of Medicine

Y. Nakagiri

Department of Orthopaedic Surgery, Kinki University School of Medicine

T. Yamane

Department of Orthopaedic Surgery, Kinki University School of Medicine

S. Fujiwara

Department of Orthopaedic Surgery, Kinki University School of Medicine

K. Katsuhisa

Department of Orthopaedic Surgery, Kinki University School of Medicine

A. Tan

Department of Orthopaedic Surgery, Kinki University School of Medicine

O. Matsuo

Department of Physiology, Kinki University School of Medicine, Osakasayama, Japan

Tissue-type plasminogen activator (t-PA), tissue-type plasminogen activator inhibitor (t-PAI), and other factors (platelets, fibrinogen, fibrinogen degrada tion products, antithrombin-III, plasminogen, and {alpha}2-plasmin inhibitor [{alpha}2-PI]) related to the fibrinolytic system were studied in 21 patients undergoing total joint replacement.

Seventeen of the 21 patients revealed an impaired fibrinolytic activity from the first to seventh postoperative day and a subsequent return to the preopera tive level by the fourteenth postoperative day. There were accompanying increases in the level of {alpha}2-PI and in the t-PAI/t-PA ratio, and there was decrease in plas minogen level. Such hypofibrinolytic states may be related to a higher incidence of postoperative thrombosis in total joint replacement patients.

Vascular and Endovascular Surgery, Vol. 26, No. 1, 59-64 (1992)
DOI: 10.1177/153857449202600110
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