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Interventricular Septal Excursions and Velocities During Experimental Myocardial Ischemia. Effects of Nitroglycerin Infusion

Deparment of Medicine, University of Patras, Patras Medical School, Greece, Department of Cardiology, University of Belfast, N. Ireland

G.M. Zavras

Deparment of Medicine, University of Patras, Patras Medical School, Greece, Department of Cardiology, University of Belfast, N. Ireland

P.J. Papadaki

Deparment of Medicine, University of Patras, Patras Medical School, Greece, Department of Cardiology, University of Belfast, N. Ireland

G.D. Soufras

Deparment of Medicine, University of Patras, Patras Medical School, Greece, Department of Cardiology, University of Belfast, N. Ireland

P.J. Vasilakos

Deparment of Medicine, University of Patras, Patras Medical School, Greece, Department of Cardiology, University of Belfast, N. Ireland

E.A. Poulos

Deparment of Medicine, University of Patras, Patras Medical School, Greece, Department of Cardiology, University of Belfast, N. Ireland

M.G. Papadimitriou

Deparment of Medicine, University of Patras, Patras Medical School, Greece, Department of Cardiology, University of Belfast, N. Ireland

G.V. Gouvelou-Deligianni

Deparment of Medicine, University of Patras, Patras Medical School, Greece, Department of Cardiology, University of Belfast, N. Ireland

The effects of intravenous nitroglycerin on the excursions and velocities of the interventricular septum were evaluated by use of ultrasound in 20 open-chest dogs during experimental myocardial ischemia. In 10 dogs with acute septal ischemia the systolic and diastolic excursions and velocities of the interventricular septum were reduced (p<0.01), but with the use of nitroglycerin, they increased as follows, although they did not return to the preischemia levels: Systolic septal excursion (p<0.01), systolic septal velocity (p<0.01), diastolic septal excursion (p = 0.01) and diastolic septal velocity (p<0.01). In 10 dogs with acute posterior wall ischemia, the mobility of the interventricular septum increased (p<0.01). This compensatory hyperactivity increased even more with the use of nitroglycerin as follows: Systolic septal excursion (p = 0.05), systolic septal velocity (p = 0.02), diastolic septal excursion (p = 0.05), and diastolic septal velocity (p<0.01). The measurements were obtained using the recently described method of the specific points. Possible mechanisms for these effects include increased regional blood flow, reduced afterload, and mechanical pulling of the ischemic myocardium.

Vascular and Endovascular Surgery, Vol. 25, No. 4, 259-266 (1991)
DOI: 10.1177/153857449102500402


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