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Vascular and Endovascular Surgery
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Antioxidant Action of Vitamins A and E in Patients Submitted to Coronary Artery Bypass Surgery

Ricardo Federico Ferreira

Department of Cardiovascular Surgery, ECAVI, Policlinico Bancario Buenos Aires

Jose Milei

Department of Cardiology, Hospital Fernandez, Buenos Aires

Susana Llesuy

Department of Biological Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina

Beatriz Gonzalez Flecha

Department of Biological Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina

Hector Hourquebie

Department of Cardiovascular Surgery, ECAVI, Policlinico Bancario Buenos Aires

Luis Molteni

Department of Cardiovascular Surgery, ECAVI, Policlinico Bancario Buenos Aires

Carlos de Palma

Department of Cardiovascular Surgery, ECAVI, Policlinico Bancario Buenos Aires

Aldo Paganini

Department of Cardiovascular Surgery, ECAVI, Policlinico Bancario Buenos Aires

Luis Scervino

Department of Cardiovascular Surgery, ECAVI, Policlinico Bancario Buenos Aires

Alberto Boveris

Department of Biological Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina

Sixteen patients submitted to coronary artery bypass grafting were divided into two groups: Group 1 served as controls, and patients in Group 2 received 400 mg of vitamin E and 100,000 IU of vitamin A orally each day for five days before surgery. During surgery biopsy samples were obtained from the apex of the left ventricle before the ischemic period and after ten minutes of reperfusion. The samples were assayed for hydroperoxide-initiated chemiluminescence to indirectly determine free radicals activity. Preischemia biopsy specimens showed a photoemission of 40.7±1 cpm/mg of protein x 10-3, and 33.0±6.3 cpm/mg of protein x 10-3 for Groups 1 and 2 respectively (p NS). For rerperfusion samples the values were 89.5±11 cpm/mg of protein x 10-3 and 23.9 ± 5 cpm/mg of protein x 10-3 for Groups 1 and 2 respectively (p<0.001). These results show that the ischemia/reperfusion mechanism increases oxidative stress and this unwished effect may be inhibited with the preoperative administration of vitamins A and E.

Vascular and Endovascular Surgery, Vol. 25, No. 3, 191-195 (1991)
DOI: 10.1177/153857449102500305
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