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Effect of Graded Aortic Occlusion on the Reticuloendothelial System

Surgical Services, Veterans Administration Medical Center and The Department of Surgery

David S. Chi

Department of Medicine, East Tennessee State University, Johnson City, Tennessee

Paul E. Stanton, JR

Surgical Services, Veterans Administration Medical Center and The Department of Surgery

To evaluate the effect of graded aortic occlusion on the reticuloendothelial system (RES), 21 Sprague Dawley rats were subjected to fifteen (GI), thirty (GII), or sixty (GIII) minutes of distal aortic occlusion or to a sixty-minute sham operation (GIV) under general anesthesia. Chromium 51-labeled sheep red blood cells (SRBC) were injected twenty-four hours later, and SRBC half-life (T) was measured as an index of RES function.

Decreased RES function was (1) dependent upon the duration of clamping time, (2) most pronounced at sixty minutes' clamping time, (3) characterized by a marked increase in SRBC half-life, along with a decreased radioactive uptake by the spleen and liver.

Vascular and Endovascular Surgery, Vol. 21, No. 6, 412-415 (1987)
DOI: 10.1177/153857448702100606


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