This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Corson, J. D. Articles by Karmody, A. M. Search for Related Content PubMed Articles by Corson, J. D. Articles by Karmody, A. M. Social Bookmarking                         What's this?

Limitations of the Use of Intra-Arterial Fibrinolytic Agents in Acute Lower Limb Ischemia

Departments of Surgery and Radiology, Albany Medical College and Veterans Administration Medical Center, Albany, New York

Benjamin B. Chang

Departments of Surgery and Radiology, Albany Medical College and Veterans Administration Medical Center, Albany, New York

Martin Goldman

Departments of Surgery and Radiology, Albany Medical College and Veterans Administration Medical Center, Albany, New York

Mohammad S. Sarrafizadeh

Departments of Surgery and Radiology, Albany Medical College and Veterans Administration Medical Center, Albany, New York

Peter W. Leopold

Departments of Surgery and Radiology, Albany Medical College and Veterans Administration Medical Center, Albany, New York

Robert P. Leather

Departments of Surgery and Radiology, Albany Medical College and Veterans Administration Medical Center, Albany, New York

Dhiraj M. Shah

Departments of Surgery and Radiology, Albany Medical College and Veterans Administration Medical Center, Albany, New York

Allastair M. Karmody

Departments of Surgery and Radiology, Albany Medical College and Veterans Administration Medical Center, Albany, New York

The use of direct regional intraarterial low dose fibrinolytic therapy was retrospectively studied in a group of 25 patients with acute lower limb ischemia. Bleeding problems were minimized due to careful monitoring of fibrinogen lev els. However two bleeding complications developed during lytic therapy on pa tients who had undergone recent surgical intervention. Following lysis a surgically correctable lesion was seen in one recently occluded conduit and in four late bypass occlusions. Eighty-three percent of the patients who had some lytic response required surgical intervention. The average time of fibrinolytic infusion was 46.7 hours.

Vascular and Endovascular Surgery, Vol. 20, No. 2, 105-111 (1986)
DOI: 10.1177/153857448602000208


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?