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Frequency of Thrombus on Non-Pathologic and Atherosclerotic Intima of Human Aorta — Thrombosis as a Pathogenesis of Atherosclerosis

Department of Pathology, Kurame University School of Medicine, Kurume, Japan

Itsuro Hayashi

Department of Pathology, Kurame University School of Medicine, Kurume, Japan

Teruyuki Nakashima

Department of Pathology, Kurame University School of Medicine, Kurume, Japan

Forty-four aortas dissected from human subjects were sliced into 30-50 se rial sections and studied morphologically for the presence of thrombi. A total of 569 thrombi were found histologically in 1,400 sections. The frequency of thrombosis was 7% for subjects under 30 years-old. However, with increasing age, the frequency rose to 8% in the third decade, 9% in the fourth decade, 13.5% in the fifth decade, 10.5% in sixth decade, 25.5% in the seventh decade and 33.5% for subjects over 80 years-old.

Thrombi were morphologically classified into three types: (1) microthrombi (2) membranous thrombi, and (3) large massive thrombi. The latter were rarely found on the intima, and no sclerotic lesions were observed.

The frequency of thrombosis on non-pathologic areas was 11 %, and almost all of them were microthrombi. The thrombi on the areas of cloudy thickening was 47% with 6% of them being classified as membranous thrombi or large massive thrombi. The thrombi on atherosclerotic lesions was 42%, unusually high compared with the other categories and 32 % of them were membranous or large massive thrombi.

In each region of thoracic and abdominal aorta, thrombi were apt to be more on abdominal aorta than that on thoracic aorta.

Vascular and Endovascular Surgery, Vol. 19, No. 2, 79-86 (1985)
DOI: 10.1177/153857448501900203


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