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First published on July 11, 2008
Vascular and Endovascular Surgery 2008, doi:10.1177/1538574408320027

Article

Associations Between Statin Treatment and Markers of Inflammation, Vasoconstriction, and Coagulation in Patients With Abdominal Aortic Aneurysm

Anders Gottsäter, MD, PhD*, Despina Flondell-Sité, MD, Tilo Kölbel, MD, PhD, and Bengt Lindblad, MD, PhD

* To whom correspondence should be addressed. E-mail: anders.gottsater{at}med.lu.se.


  Abstract
The association of statins with markers of inflammation, vasoconstriction, and coagulation was evaluated in 325 patients with abdominal aortic aneurysm with respect to statin treatment or not. Variables evaluated included routine laboratory markers, lipids, homocysteine, endothelin-1, matrix metalloproteinases (MMP)-2 and -9, and activated protein C-protein C inhibitor (APC-PCI) complex. Statin-treated patients were more often male (85% vs 75%; P = .024) and had ischemic heart disease (57% vs 19%; P < .0001). They showed lower levels of cholesterol (P< .0001), homocysteine (P = .027), MMP-9 (P = .038), and endothelin-1 (P = .005),and higher levels of APC-PCI complex (P = .042). Differences persisted in logistic regression for cholesterol (P < .0001), APC-PCI complex (P = .034), and homocysteine (P = .021). Statin-treated patients with abdominal aortic aneurysm show higher APC-PCI complex and lower homocysteine levels. Whether this translates into lower risk for aneurysm expansion or rupture will be evident from further follow-up.


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