Vascular and Endovascular Surgery

 

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First published on March 3, 2008, doi:10.1177/1538574408314437

Vascular and Endovascular Surgery 2008;42:249.

A more recent version of this article appeared on June 1, 2008

Article

High-Sensitivity CRP Is Correlated With Neurologic Symptoms and Plaque Instability in Patients With Severe Stenosis of the Carotid Bifurcation

THEOPHANIS T. PAPAS*, CHRYSOSTOMOS MALTEZOS, NIKOLAOS PAPANAS, GEORGIOS KOPADIS, JOANNIS MARAKIS, EFSTRATIOS MALTEZOS, and ELIAS BASTOUNIS

* To whom correspondence should be addressed. E-mail: pfanis{at}otenet.gr.


  Abstract
The aim of this study is to investigate the correlation of high-sensitivity C-reactive protein and E-selectin with clinical manifestations and plaque characteristics in 88 patients (69 with and 19 without neurological symptoms) with high-grade stenosis of the carotid bifurcation who underwent endarterectomy. The grade of stenosis was quantified by duplex ultrasonography and digital subtraction angiography. Preoperatively, serum high-sensitivity C-reactive protein and E-selectin were measured. Postoperatively, carotid plaque morphology was established according to the American Heart Association classification. High-sensitivity C-reactive protein levels were significantly (P< .001) higher in symptomatic than in asymptomatic patients, as well as in patients with unstable compared with those with stable plaques (P< .001). Serum high-sensitivity C-reactive protein levels correlated significantly (P< .05) with macrophage count on the plaque. In conclusion, serum high-sensitivity C-reactive protein levels are associated with presence of neurological symptoms and plaque instability in patients with high-grade stenosis of the carotid bifurcation.


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