This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Mitchell, R. S. Articles by Stinson, E. B. Search for Related Content PubMed Articles by Mitchell, R. S. Articles by Stinson, E. B. Social Bookmarking                         What's this?

Comprehensive Assessment of the Safety, Durability, Clinical Performance, and Healing Characteristics of a Double Velour Knitted Dacron Arterial Prosthesis

Stanford University Medical Center, Stanford, California

Craig Miller

Stanford University Medical Center, Stanford, California

Margaret E. Billingham

Stanford University Medical Center, Stanford, California

John T. Mehigan

Stanford University Medical Center, Stanford, California

Cornelius Olcott, IV

Stanford University Medical Center, Stanford, California

Edward B. Stinson

Stanford University Medical Center, Stanford, California

A resurgence of clinical reports documenting various modes of prosthetic graft failure have appeared recently in the literature. Increasing federal scrutiny and patient longevity make evaluation of graft durability and graft- related complications timely and imperative. Between October 1975 and February 1979, 298 patients underwent 310 arterial reconstructions using a single model of a porous double velour knitted Dacron graft. Average age was 61 ± 11 years (±SD) and males comprised 65% of the patient population. Two hundred forty-seven prosthetic grafts (80%) were used for aorto-iliac femoral reconstruction. Indications for operation included disabling claudi cation in 105 patients (35%), limb salvage in 71 patients (24%), aneurysm in 97 patients (33%), and other conditions in 25 patients. Follow-up averaged 1.8 years, extended to a maximum of 3.6 years, and yielded an aggregate of 475 graft-years of follow-up for analysis. Operative and late mortality rates were 10 and 10.8%, respectively; overall actuarial survival rate was 72 ± 4% (±SEM) at 3.1 years. Actuarial analysis showed that the probability of being free of unsalvageable graft thrombosis was 97 ± 1% at 1.7 years; of being free of graft infection, 96 ± 2% at 2.9 years; and of being free of major amputation, 95 ± 1% at 2.4 years. No late deaths or amputations were attributable to intrinsic graft failure, but one late death was related to reoperation for graft infection. Ongoing follow-up has failed to reveal any propensity for late graft dilatation, hemorrhage, or structural failure. Gross and histologic character istics of explanted grafts were uniformly favorable (in the absence of graft infection) including a thin, smooth, and translucent neointimal lining and densely adherent external encapsulation.

Vascular and Endovascular Surgery, Vol. 14, No. 3, 197-212 (1980)
DOI: 10.1177/153857448001400307


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?